Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11chigh dendritic cells
نویسندگان
چکیده
منابع مشابه
TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens.
The control of systemic infection by encapsulated microorganisms requires T-independent type II (TI-2) Ab responses to bacterial polysaccharides. To understand how such responses evolve, we explored the function of transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI), a member of the TNFR family, required for TI-2 Ab production. Quasimonoclonal (QM) mice produce ro...
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Unlike T-dependent immune responses against protein antigens, T-independent responses against polysaccharides confer long-lasting humoral immunity in the absence of recall responses and are not known to generate memory B cells. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. Furthermore, memory B cell re...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200636356